{"id":39,"date":"2020-09-10T20:01:45","date_gmt":"2020-09-10T11:01:45","guid":{"rendered":"http:\/\/charge-syndrome.net\/?page_id=39"},"modified":"2025-12-23T11:30:16","modified_gmt":"2025-12-23T02:30:16","slug":"%e5%8e%9f%e5%9b%a0%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%ae%e7%99%ba%e8%a6%8b%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6","status":"publish","type":"page","link":"https:\/\/charge-syndrome.net\/?page_id=39","title":{"rendered":"\u539f\u56e0\u907a\u4f1d\u5b50\u306e\u767a\u898b\u306b\u3064\u3044\u3066"},"content":{"rendered":"\n

\u30aa\u30e9\u30f3\u30c0\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3088\u308a CHARGE\u75c7\u5019\u7fa4(\u9023\u5408) \u306e\u539f\u56e0\u907a\u4f1d\u5b50\u304c\u767a\u898b\u3055\u308c\u305f\u3068\u3044\u3046\u5831\u544a\u304c\u306a\u3055\u308c\u307e\u3057\u305f\u3002
\u8a73\u3057\u304f\u306f\u4e0b\u8a18\u3092\u3054\u3089\u3093\u4e0b\u3055\u3044\u3002<\/p>\n\n\n\n

\u306a\u304a\u3001\u3053\u308c\u306b\u4f34\u3044\u3001\u8840\u6db2\u691c\u67fb\u7b49\u306e\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u5f53\u4f1a\u306f\u8cdb\u6210\u30fb\u53cd\u5bfe\u306e\u3044\u305a\u308c\u306e\u7acb\u5834\u3082\u3068\u3063\u3066\u304a\u308a\u307e\u305b\u3093\u3002
\u3042\u304f\u307e\u3067\u3001\u5404\u3054\u5bb6\u5ead\u306e\u81ea\u7531\u306a\u610f\u601d\u3067\u6c7a\u5b9a\u3055\u308c\u307e\u3059\u3088\u3046\u3001\u304a\u9858\u3044\u7533\u3057\u4e0a\u3052\u307e\u3059\u3002<\/p>\n\n\n\n

1.<\/strong><\/td>
\u30aa\u30e9\u30f3\u30c0\u306e\u30ca\u30a4\u30e1\u30fc\u30d8\u30f3\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u3063\u3066Nature Genetics\u3068\u3044\u3046\u6a29\u5a01\u3042\u308b\u5b66\u8853\u96d1\u8a8c\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u306b\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002
<\/td><\/tr>
2.<\/strong><\/td>\u8ad6\u6587\u306e\u8981\u65e8<\/strong> <\/td><\/tr>
<\/td>\u30de\u30a4\u30af\u30ed\u30fb\u30a2\u30ec\u30a4\u6cd5(\u67d3\u8272\u4f53\u306e\u5c0f\u3055\u304f\u6b20\u3051\u3066\u3044\u308b(\u6b20\u5931)\u90e8\u5206\u3092\u691c\u67fb\u3067\u304d\u308b\u65b0\u3057\u3044\u89e3\u6790\u6280\u8853)\u3092\u7528\u3044\u3066\u30012\u540d\u306eCHARGE\u75c7\u5019\u7fa4\u3092\u6709\u3059\u308b\u60a3\u8005\u3055\u3093\u306b\u7b2c8\u756a\u67d3\u8272\u4f53\u306eq12\u3068\u3044\u3046\u90e8\u4f4d\u306b\u3001\u67d3\u8272\u4f53\u306e\u5fae\u5c0f\u306e\u6b20\u5931\u304c\u898b\u3044\u3060\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u5c0f\u3055\u306a\u6b20\u5931\u304c\u4ed6\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3082\u8a8d\u3081\u308b\u304b\u3069\u3046\u304b\u3092\u300117\u540d\u306eCHARGE\u306e\u60a3\u8005\u3055\u3093\u306b\u3064\u3044\u3066\u8abf\u3079\u307e\u3057\u305f\u304c\u3001\u540c\u3058\u3088\u3046\u306a\u6b20\u5931\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002

\u305d\u3053\u3067\u3001\u306f\u3058\u3081\u306e\u3075\u305f\u308a\u306e\u60a3\u8005\u3055\u3093\u306b\u8a8d\u3081\u3089\u308c\u305f\u3001\u5c0f\u3055\u306a\u6b20\u5931\u306e\u4e2d\u306b\u5b58\u5728\u3059\u308b9\u3064\u306e\u907a\u4f1d\u5b50\u306e\u907a\u4f1d\u6697\u53f7\u306e\u914d\u5217\u3092\u3059\u3079\u3066\u8abf\u3079\u305f\u3068\u3053\u308d\u3001CHD7\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306b\u300117\u540d\u4e2d10\u540d(59%)\u306b\u3001\u5909\u7570(\u907a\u4f1d\u6697\u53f7\u306e\u914d\u5217\u306e\u9055\u3044)\u304c\u898b\u3044\u3060\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u3053\u306eCHD7\u3068\u3044\u3046\u907a\u4f1d\u5b50\u304c\u539f\u56e0\u907a\u4f1d\u5b50\u306e\u3072\u3068\u3064\u3067\u3042\u308b\u3068\u7d50\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u3001\u67d3\u8272\u4f53\u306e\u6b20\u5931\u3067\u3001\u3053\u306e\u907a\u4f1d\u5b50\u3092\u5931\u3063\u3066\u304a\u308a\u6a5f\u80fd\u3057\u306a\u3044\u3001\u3042\u308b\u3044\u306f\u3001\u907a\u4f1d\u5b50\u306e\u4e2d\u306b\u5909\u7570\u304c\u3042\u3063\u3066\u6a5f\u80fd\u3057\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u304c\u539f\u56e0\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002

\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u8a8d\u3081\u3089\u308c\u305f\u60a3\u8005\u3055\u3093\u3067\u3001\u4e21\u89aa\u3001\u3042\u308b\u3044\u306f\u4e21\u89aa\u306e\u4e00\u65b9\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u30928\u5bb6\u65cf\u3067\u884c\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3059\u3079\u3066\u306e\u89aa\u306b\u306f\u907a\u4f1d\u5b50\u306e\u5909\u5316\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3059\u306a\u308f\u3061\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u5316\u306f\u3001\u4eca\u56de\u8abf\u3079\u305f\u5bb6\u65cf\u3067\u306f\u3001\u7a81\u7136\u5909\u7570\u3067\u751f\u3058\u305f\u3068\u306e\u3053\u3068\u3067\u3057\u305f\u3002

CHD7\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306f\u3001Chromodomain\u00a0Helicase\u00a0DNA-binding\u907a\u4f1d\u5b50\u3068\u547c\u3070\u308c\u308b\u3082\u306e\u306e\u3072\u3068\u3064\u3067\u3042\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u304b\u3089\u3064\u304f\u3089\u308c\u308b\u305f\u3093\u3071\u304f\u8cea\u306f\u3001\u67d3\u8272\u4f53\u306e\u69cb\u9020\u3084\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u4f5c\u7528\u3057\u3001\u80ce\u751f\u521d\u671f\u306e\u767a\u751f\u306b\u91cd\u8981\u306a\u50cd\u304d\u3092\u6709\u3059\u308b\u3068\u63a8\u6e2c\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3044\u307e\u3060\u305d\u306e\u50cd\u304d\u306f\u8a73\u3057\u304f\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u305f\u3093\u3071\u304f\u8cea\u306f\u3001\u80ce\u751f\u671f\u3001\u307e\u305f\u6210\u4eba\u306e\u773c\u3001\u8133\u3001\u5185\u8033\u3001\u80c3\u3001\u8178\u3001\u5fc3\u81d3\u306a\u3069\u306b\u307f\u3089\u308c\u307e\u3059\u3002
\u00a0<\/td><\/tr>
3.<\/strong><\/td>CHARGE\u75c7\u5019\u7fa4\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u767a\u898b\u306b\u3064\u3044\u3066\u306e\u30b3\u30e1\u30f3\u30c8<\/strong><\/td><\/tr>
<\/td>\u30fb\u3072\u3068\u3064\u306e\u8ad6\u6587\u3060\u3051\u3067\u3059\u306e\u3067\u3001\u305d\u306e\u610f\u7fa9\u3092\u8ad6\u3058\u308b\u306b\u306f\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u3092\u5f85\u3064\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u4eca\u56de\u306e\u8ad6\u6587\u3067\u306f\u3001CHARGE\u3092\u6301\u3064\u60a3\u8005\u3055\u3093\u306e\u7d04\u534a\u6570\u304c\u3053\u306e\u907a\u4f1d\u5b50\u304c\u539f\u56e0\u3067\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e16\u754c\u306e\u3069\u3053\u306e\u56fd\u306eCHARGE\u306e\u60a3\u8005\u3055\u3093\u3082\u3001\u672c\u907a\u4f1d\u5b50\u304c\u539f\u56e0\u306a\u306e\u304b\u3069\u3046\u304b\u306e\u66f4\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\u3002\u307e\u305f\u3001\u65e5\u672c\u4eba\u306eCHARGE\u306e\u60a3\u8005\u3055\u3093\u3067\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u5316\u3092\u6709\u3059\u308b\u4eba\u304c\u3044\u3089\u3063\u3057\u3083\u308b\u306e\u304b\u3001\u307e\u305f\u3001\u3069\u308c\u304f\u3089\u3044\u306e\u983b\u5ea6\u306a\u306e\u304b\u3082\u73fe\u5728\u306f\u672a\u77e5\u3067\u3042\u308a\u307e\u3059\u3002

\u30fb\u4eca\u56de\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u306f\u3001\u307e\u3060\u3088\u304f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u6210\u4eba\u306b\u306a\u3063\u3066\u3082\u773c\u3001\u8133\u3001\u8778\u725b\u306a\u3069\u3067\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u5927\u4eba\u306b\u306a\u3063\u3066\u304b\u3089\u3082\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u5404\u90e8\u4f4d\u3067\u4f55\u3089\u304b\u306e\u50cd\u304d\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u63a8\u6e2c\u3055\u308c\u307e\u3059\u3002\u3088\u3063\u3066\u3001\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u306e\u7814\u7a76\u304c\u3055\u3089\u306b\u9032\u3080\u3053\u3068\u306b\u3088\u3063\u3066\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u7d50\u3073\u3064\u304f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002

\u30fb\u65e5\u672c\u4eba\u306b\u304a\u3044\u3066\u3082CHARGE\u306e\u60a3\u8005\u3055\u3093\u304c\u3001\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u3082\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308c\u3070\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066\u78ba\u5b9a\u8a3a\u65ad\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u75c7\u72b6\u306e\u7d44\u307f\u5408\u308f\u305b\u304b\u3089\u300c\u7591\u3044\u300d\u3068\u8a00\u308f\u308c\u3066\u3044\u305f\u5834\u5408\u306b\u3001\u907a\u4f1d\u5b50\u306e\u5909\u5316\u304c\u3042\u308c\u3070\u3001CHARGE\u75c7\u5019\u7fa4\u306f\u78ba\u5b9a\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002

\u30fb\u3057\u304b\u3057\u3001\u75c7\u72b6\u306e\u7d44\u307f\u5408\u308f\u305b\u304b\u3089\u3001\u660e\u3089\u304b\u306bCHARGE\u75c7\u5019\u7fa4\u3068\u8a3a\u65ad\u3092\u53d7\u3051\u3066\u3044\u308b\u5834\u5408\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u3057\u3066\u5909\u7570\u304c\u306a\u304b\u3063\u305f\u3068\u3044\u3063\u3066\u3001CHARGE\u75c7\u5019\u7fa4\u3067\u306f\u306a\u304b\u3063\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002

\u30fb\u4eca\u5f8c\u3001CHARGE\u75c7\u5019\u7fa41\u578b(\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u65b9)\u3001CHARGE\u75c7\u5019\u7fa42\u578b(\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u305f\u306a\u3044\u65b9)….\u3068\u3044\u3046\u3088\u3046\u306b\u5206\u985e\u3055\u308c\u3066\u3086\u304f\u3053\u3068\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002

\u30fb\u4eca\u5f8c\u3001\u907a\u4f1d\u5b50\u306e\u5909\u5316\u306e\u6709\u7121\u3001\u3055\u3089\u306b\u907a\u4f1d\u5b50\u5909\u5316\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u3001\u75c7\u72b6\u3084\u6210\u9577\u3001\u767a\u9054\u306e\u7a0b\u5ea6\u306b\u9055\u3044\u304c\u3042\u308b\u306e\u304b\u3001\u76f8\u95a2\u304c\u3042\u308b\u306e\u304b\u306a\u3044\u306e\u304b\u3068\u3044\u3046\u7814\u7a76\u304c\u9032\u3080\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u305d\u308c\u3089\u306e\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u5b50\u3069\u3082\u3055\u3093\u500b\u4eba\u500b\u4eba\u306b\u3042\u3063\u305f\u6cbb\u7642\u30fb\u7642\u80b2\u304c\u53ef\u80fd\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002
<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

\u30aa\u30e9\u30f3\u30c0\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3088\u308a CHARGE\u75c7\u5019\u7fa4(\u9023 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-39","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/charge-syndrome.net\/index.php?rest_route=\/wp\/v2\/pages\/39","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/charge-syndrome.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/charge-syndrome.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/charge-syndrome.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/charge-syndrome.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=39"}],"version-history":[{"count":7,"href":"https:\/\/charge-syndrome.net\/index.php?rest_route=\/wp\/v2\/pages\/39\/revisions"}],"predecessor-version":[{"id":308,"href":"https:\/\/charge-syndrome.net\/index.php?rest_route=\/wp\/v2\/pages\/39\/revisions\/308"}],"wp:attachment":[{"href":"https:\/\/charge-syndrome.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=39"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}